In a large mixing bowl, combine the ground beef, panko, egg, milk, salt, pepper, garlic, Worcestershire sauce and ketchup. Use your hands or a spoon to mix the ingredients thoroughly until well combined.
Divide the meat mixture into 4 equal portions. Use your hands to shape each portion into a patty, ensuring they are of uniform size and thickness for even cooking.
Preheat your grill or skillet over medium-high heat. If using a grill, lightly oil the grates to prevent sticking. Once the grill or skillet is hot, place the burger patties on the cooking surface. Cook for about 4 to 5 minutes on each side, or until the burgers reach your desired level of doneness.
Remove the burgers from the heat and onto a paper towel lined plate and let them rest for a few minutes before serving. This allows the juices to redistribute and ensures a juicy, flavorful burger.